OEA (oleoylethanolamide) is a compound naturally produced by the body and plays an important role in regulating metabolism, energy balance, and appetite control. OEA is involved in the regulation of dietary fat consumption, intestinal motility, and influences eating behaviours, which makes it an interesting target for improving metabolic health.

This study investigates how OEA, affects your gut microbiome composition and metabolic health markers. Research suggests that OEA may beneficially modify gut bacteria and improve metabolic outcomes. This study will help us understand how OEA affects specific gut bacteria and related metabolic markers in healthy individuals, potentially contributing to new insights into supporting healthy gut function and metabolic wellness.

Your involvement in this study will be approximately 8 weeks. You will attend 3 brief clinic visits at the RDC Clinical site in Fortitude Valley. There are no overnight stays required. Each clinic visit will take approximately 30 mins. 

You will take a daily supplement (capsule) at home for 8 weeks between your baseline and final visits. 

As the recruitment for this study is expected to be over several months, your start date is flexible and can be at a day/time that is convenient for you. 

Please see below for more information. You can also register your interest using the form at the bottom of this page.

OEA (oleoylethanolamide) is a compound naturally produced by the body and plays an important role in regulating metabolism, energy balance, and appetite control. OEA is involved in the regulation of dietary fat consumption, intestinal motility, and influences eating behaviours, which makes it an interesting target for improving metabolic health.

This study is designed to examine the effects of OEA compared to a placebo over 8-week period. This is a double-blind, randomised, placebo-controlled study. 

It is hypothesised that the consumption of OEA will reduce plasma imidazole propionate levels by modulating gut microbiome composition, particularly reducing histidine-metabolizing bacteria, leading to improved insulin sensitivity and metabolic health.

The product will be supplied in capsule form, and participants will be required to take two capsules daily for 8 weeks. 

Your involvement in the study will be for approximately 8 weeks during which time you will attend 3 short clinic visits. There are no overnight stays required in this study. 

During the study, you will be asked to:

• Attend our clinic on three occasions for approximately 30 mins per visit (Baseline, Week 4 and End of Study Week 8).
• Take two study product capsules daily at home for 56 consecutive days. 
• Collect a smear of stool sample at baseline and end of study.*
• Have a blood sample collected at all clinic visits.

*The stool sample will be collected at home using a kit that we provide. The sample required is a small smear. 

The information we collect during the study will enable investigators to assess how the product affects your gut microbiome composition and metabolic health markers in your blood.

Please note: This page is a summary of the study outline and participant requirements. A full Participant Information Sheet with detailed information will be provided to you before you are asked to give your consent to participate.

Upon completion of the study requirements, you will be eligible for a $600 payment for your time and travel expenses. The payment will be made by gift voucher or via direct deposit to your nominated bank account (your choice) once all study requirements have been met. 

If you are interested in participating, we’d love to hear from you. Please register your interest by answering the questionnaire and completing the form on this page…we’ll then get in touch to screen you for eligibility.

Our clinic is located on Level 3, 252 St Pauls Terrace, Fortitude Valley.

We have free undercover parking for participants directly next door under the Kennigo Hotel, 22 Kennigo Street, Fortitude Valley.

Getting to Us

• Private Transport: free undercover parking available at Kennigo Hotel Car Park
• Train: Fortitude Valley Train Station (350m away)
• Bus: multiple bus stops within close proximity

• Adults 18 years old and over 
• BMI between 24.9 and 34.9 kg/m² (you can check your BMI using the calculator on this page)
• Generally healthy 
• Able to provide informed consent
• Able to commit to completing the study requirements 

Please register your interest by answering the questionnaire and completing the form on this page… we’ll then get in touch to screen you for suitability.

Please note: This page is a summary of the study outline and participant requirements. A full Participant Information Sheet with more detailed information will be provided to you before you are asked to give your consent to participate.

This RDC Clinical study has been approved by the Bellberry Human Research Ethics Committee under Approval Number: 2025-11-1911. The study is also registered on the clinicaltrials.gov under Registration Number: NCT07457723. 

Trained trial coordinators will supervise your progress throughout the study. Your results will be made available to you at the conclusion of the study. Any of your personal information collected during the study will be kept in the strictest confidence.